Dataset features

Specifications


Application: RNA-seq analysis
Number of samples: 94
Release date: Oct 16 2018
Last update date: Nov 20 2018
Access: Public
Diseases: Kidney Diseases, Kidney Diseases, Cystic
Dataset link Evaluation of APOL1 ASO in a novel model of APOL1-associated renal disease

Experimental Protocol


APOL1 G0 and G1 transgenic mice were dosed with PBS (vehicle), 50 mg/kg control ASO (non-targeting ASO of the same chemistry as targeting ASO) or 50 mg/kg APOL1 ASO once/week for 4 weeks. One day after the last ASO dose, cohorts were divided and half were challenged with PBS and half were challenged with IFNgamma. Kidney and Liver tissues were harvested 48 hours after challenge for analysis. N=3-4 per group.

Repositories


GEO

GSE121286

ENA

SRP165796

BioProject

PRJNA496524

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Contact


Sagar Damle