|Application:||Gene expression microarray analysis|
|Number of samples:||8|
|Release date:||Dec 28 2012|
|Last update date:||Aug 13 2018|
|Diseases:||Nervous System Diseases|
|Dataset link||Senescence impairs direct conversion of human somatic cells to neurons|
Transient knockdown of p16/p19 or p53 expression or exogenous overexpression of hTERT can induce primary fibroblasts to immortality. In the following, treated cells were cultured in neuron-induction medium. We can observe the morphology change and detect the neuronal markers. Also, some of the induced neurons could generate action potentials and neurotransmitter-induced currents in optimal conditions.
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