Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 8
Release date: Dec 28 2012
Last update date: Aug 13 2018
Access: Public
Diseases: Nervous System Diseases
Dataset link Senescence impairs direct conversion of human somatic cells to neurons

Experimental Protocol


Transient knockdown of p16/p19 or p53 expression or exogenous overexpression of hTERT can induce primary fibroblasts to immortality. In the following, treated cells were cultured in neuron-induction medium. We can observe the morphology change and detect the neuronal markers. Also, some of the induced neurons could generate action potentials and neurotransmitter-induced currents in optimal conditions.

Repositories


GEO

GSE43175

ArrayExpress

E-GEOD-43175

BioProject

PRJNA184842

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Contact


chongkui sun

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