|Application:||Gene expression microarray analysis|
|Number of samples:||16|
|Release date:||Mar 3 2016|
|Last update date:||Jun 9 2017|
|Dataset link||The Adaptive Immune System Restrains Alzheimer’s Disease (AD) Pathogenesis by Modulating Microglial Function|
To examine the impact of the adaptive immune system on AD pathogenesis, we backcrossed a well-established AD transgenic line, 5xfAD mice [Oakley et al., 2006], on to a Rag2-/-/Il2rγ-/- double knockout background, creating mice that lacked T-cells, B-cells, and NK-cells. In the process of generating these immune-deficient “Rag-5xfAD” and “Rag-WT” littermates, we also produced strain-matched equivalent immune-competent AD transgenic and wild-type mice termed “WT-5xfAD” and “WT-WT” respectively.