Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 16
Release date: Mar 3 2016
Last update date: Jun 9 2017
Access: Public
Diseases: Alzheimer Disease
Dataset link The Adaptive Immune System Restrains Alzheimer’s Disease (AD) Pathogenesis by Modulating Microglial Function

Experimental Protocol


To examine the impact of the adaptive immune system on AD pathogenesis, we backcrossed a well-established AD transgenic line, 5xfAD mice [Oakley et al., 2006], on to a Rag2-/-/Il2rγ-/- double knockout background, creating mice that lacked T-cells, B-cells, and NK-cells. In the process of generating these immune-deficient “Rag-5xfAD” and “Rag-WT” littermates, we also produced strain-matched equivalent immune-competent AD transgenic and wild-type mice termed “WT-5xfAD” and “WT-WT” respectively.

Repositories


GEO

GSE77574

BioProject

PRJNA310838

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Contact


Mathew Blurton-Jones