Computational protocol: Plasmodium falciparum Adhesins Play an Essential Role in Signalling and Activation of Invasion into Human Erythrocytes

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Protocol publication

[…] P. falciparum EBL and PfRh adhesin family tail domains were defined as residues C-terminal to their respective TM domains which are previously published (Baker et al., 2006). Tail sequences were retrieved from the PlasmoDB database (http://plasmodb.org/plasmo/) and entered into the NetPhos v2.0 (www.cbs.dtu.dk/services/NetPhos/) search engine to determine serine/threonine/tyrosine sites (phosphosites) likely to be phosphorylated (Blom et al., 1999). Sequences were submitted to NetPhosK v1.0 (www.cbs.dtu.dk/services/NetPhosK/) to predict site-specific kinases for adhesin tail sequence []. […]

Pipeline specifications

Software tools NetPhos, NetPhosK
Databases PlasmoDB
Application PTM analysis
Organisms Plasmodium falciparum, Homo sapiens, Toxoplasma gondii
Diseases Malaria