Computational protocol: Involvement of PINK1/parkin-mediated mitophagy in ZnO nanoparticle-induced toxicity in BV-2 cells

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Protocol publication

[…] Data were evaluated by SPSS (version 20, IBM, Armonk, NY, USA) software using two-way analysis of variance (ANOVA) and the Student Newman–Keuls test (SNK) with the cell line and the concentrations of ZnO NPs as variables in the evaluation of cell survival. One-way ANOVA was used with the cell line as the variable in the evaluation of cell viability, ROS amount, JC-1 amount, and MDC fluorescence intensity. All the Western blot results were quantified by ImageJ 1.48v. Differences were considered significant when P<0.05. […]

Pipeline specifications

Software tools SPSS, ImageJ
Applications Miscellaneous, Microscopic phenotype analysis
Diseases Neurotoxicity Syndromes, Mitochondrial Diseases, Drug-Related Side Effects and Adverse Reactions
Chemicals Zinc Oxide