Computational protocol: Altered responsiveness of BNST and amygdala neurons in trauma-induced anxiety

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Protocol publication

[…] The data were analyzed offline with the software IGOR (Wavemetrics, Portland, OR, USA), clampfit (Axon instruments, Foster City, CA, USA), and custom software written using Numpy and Scipy ( Values are expressed as means±s.e.m. All statistical tests are two-sided. In all cases, all available cells, trials and subjects are included in the statistical analyses, as appropriate. The tests aimed to determine whether there were differences between neurons recorded in the two rat phenotypes. Depending on sample sizes, we used X2- or Fisher's exact tests to determine if phenotypic differences in the incidence of different cells types were significant. To compare their electroresponsive properties, we used non-parametric Kruskal–Wallis one-way analysis of variance (ANOVA). Since the synaptic responsiveness data were distributed normally, we used repeated measures ANOVAs for these comparisons. […]

Pipeline specifications

Software tools Numpy, SciPy
Applications Miscellaneous, WGS analysis
Organisms Homo sapiens, Rattus norvegicus