Dataset features

Specifications


Application: DNA methylation array analysis
Number of samples: 8
Release date: May 17 2016
Last update date: May 17 2016
Access: Public
Diseases: Carcinoma, Hepatocellular, Neoplasms, Tumor Lysis Syndrome, Chronobiology Disorders, Hypoalphalipoproteinemias
Chemicals: Phenobarbital
Genes: ETL, Tet1
Dataset link IP of 5-hydroxymethylcytosine (5-hmC) enriched DNA fragments from control ,PB treated mouse livers , resulting Ctnnb1 mutated PB liver tumours and PB minus Ha-Ras mutate liver tumour

Experimental Protocol


5-hmC is a novel epigenetic mark derived from oxidation of methylcytosine. Phenobarbital (PB) is a well studied non-genotoxic carcinogen with roles in epigenetic perturbation. We profile 5hmC in both control mouse livers as well as in the livers of 12 week PB treated mice. We also profile 5hmC in liver tumours arising in the presence of long term PB exposure (35 week: resulting in Ctnnb1 mutated tumours) to a Ha-Ras liver tumour which arose without PB. Samples: 5hmC profiles in 2 control and 2 PB exposed mouse livers, 3 liver tumours resulting from long term PB exposrue and 1 liver tumour arising without PB

Repositories


GEO

GSE77726

ArrayExpress

E-GEOD-77726

BioProject

PRJNA311322

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Contact


John Thomson
John Paterson Thomson