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Protocol publication

[…] Two independent investigators (LD and PE) manually segmented the lesions on the native T1 images using MRIcron software (modified kappa, κ = 0.82) (). After the native images and lesions had been normalized to the MNI (Montreal Neurological Institute) template (FSL), volumes expressed in mm3 were automatically calculated for each patient (Fsl.anat toolbox). [...] Analyses were carried out using χ2 for nominal data. We used the nonparametric MannWhitney U test for comparisons between patients and controls, but opted for a permutation test, a procedure suitable for small sample size, to compare the performances of the dMTT and iMTT subgroups ().Analyses were carried out with Statistica Version 8 and the coin (Conditional Inference Procedures in a Permutation Test Framework) package in R Version 3.0.3. Spearman’s rho was used for nonparametric correlations. The level of significance was set at p=0.05. For the correlation analyses, d’, R and F indices were averaged after they had been z-transformed according to the controls’ means and standard deviations. We computed a nonparametric effect size based on ranks (). This effect size can range from 0.5 to 1, with an A (measure of stochastic superiority) of between. 56 and. 64 corresponding to a small effect, one between 0.65 and 0.71 to a medium effect and one above. 71 to a large effect (equivalent values for Cohen’s d of 0.2, 0.5 and 0.8). Multiple comparisons were corrected using the Bonferroni-Holm correction (). […]

Pipeline specifications

Software tools MRIcron, Statistica
Applications Miscellaneous, Magnetic resonance imaging
Organisms Homo sapiens
Diseases Myoclonic Cerebellar Dyssynergia, Nervous System Diseases, Thalamic Diseases, Stroke