Dataset features

Specifications


Application: RNA-seq analysis
Number of samples: 68
Release date: Dec 2 2014
Last update date: Oct 24 2018
Access: Public
Chemicals: Tunicamycin
Dataset link The genetic architecture of the genome-wide transcriptional response to ER stress in the mouse

Experimental Protocol


We investigated the genetic variation in ER stress transcriptional response in mouse embryonic fibroblasts (MEFs) across eight mouse strains: A/J, C57BL/6J, 129S1Sv/ImJ, NOD/ShiLtJ, NZO/H1LtJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ. MEFs from each strain were treated with a control DMSO or ER stress-inducing drug, Tunicamycin (TM). To identify the genetic architecture underlying this genetic variation, MEFs from F1 strains were also studied. MEFs from the following F1s were evaluated: C57BL/6J X CAST/EiJ, C57BL/6J X 129S1Sv/ImJ, C57BL/6J X NOD/ShiLtJ, C57BL/6J X NZO/H1LtJ, and C57BL/6J X WSB/EiJ. Again F1 MEFS were treated with either DMSO or TM. There are two or three replicates for each sample.

Repositories


GEO

GSE63756

ArrayExpress

E-GEOD-63756

ENA

SRP050399

BioProject

PRJNA268980

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Contact


Clement Chow
Clement Y Chow

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