|Number of samples:||9|
|Release date:||Aug 21 2012|
|Last update date:||Jan 23 2018|
|Diseases:||Cluster Headache, Leukemia, Myeloid, Myeloproliferative Disorders, Neural Tube Defects, Leukemia, Myeloid, Acute|
|Dataset link||ASXL1 Mutations Promote Myeloid Transformation Through Loss of PRC2-Mediated Gene Repression|
To assess the genome-wide effects of ASXL1 loss on chromatin state we performed chromatin immunoprecipitation followed by next generation sequencing (CHIP-seq) for histone modifications known to be associated with PcG (histone H3 lysine 27 trimethylation (H3K27me3)) or TxG activity (histone H3 lysine 4 trimethylation (H3K4me3)) in UKE1 cells expressing empty vector (EV) or 2 independent validated shRNAs for ASXL1. This Series represents the ChIP-Seq data (not the microarray data referenced in the summary above). The related micorarray data are available in GEO as GSE38692.