Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 58
Release date: Nov 14 2008
Last update date: Jul 1 2016
Access: Public
Diseases: Carcinoma, Squamous Cell, Neoplasms, Tongue Diseases, Tongue Neoplasms
Dataset link Oral tongue cancer gene expression profiling: Identification of novel potential prognosticators

Experimental Protocol


The gene expression profile of patients (n=37) with oral tongue SCC were analyzed using Affymetrix HG_U95Av2 high-density oligonucleotide arrays. Hierarchical clustering analyses failed to show significant segregation of patients. In patients (n=20) with available tumor and matched normal mucosa, 77 genes were found to be differentially expressed (P< 0.05) in the tongue tumor samples compared to their matched normal controls. Among the 45 over-expressed genes, MMP-1 encoding interstitial collagenase showed the highest level of increase (average: 34.18 folds). The 20 patients were then grouped into stage (early vs. late) and nodal disease (node positive vs. node negative) subgroups and genes differentially expressed in tumor vs. normal and between the subgroups were identified. Three genes, GLUT3, HSAL2, and PACE4, were selected for their potential biological significance in a larger cohort of 49 patients by quantitative real-time RT-PCR

Repositories


GEO

GSE13601

ArrayExpress

E-GEOD-13601

BioProject

PRJNA110219

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Contact


Nicholas Socci
Nicholas D Socci

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