Computational protocol: Aerobic fitness is associated with greater white matter integrity in children

Similar protocols

Protocol publication

[…] Image analyses and tensor calculations were performed using FSL 5.0.1 (FMRIB Software Library). First, each participant’s data were passed through an automated pipeline consisting of (1) motion and eddy current correction, (2) removal of non-brain tissue using the Brain Extraction Tool (), and (3) local fitting of the diffusion tensor model at each voxel using FMRIB’s Diffusion Toolbox v2.0 (FDT). The products of the multi-step pipeline included FA and AD images; RD maps were calculated as the mean of the second and third eigenvalues ().Next, diffusion data were processed using TBSS v1.2 (Tract-Based Spatial Statistics; ). Each participant’s FA data were aligned into the 1 mm × 1 mm × 1 mm standard Montreal Neurological Institute (MNI152) space via the FMRIB58_FA template using the FMRIB’s Non-linear Registration Tool (,), and a mean diffusion image was created. The mean FA image was then thinned to create an average skeleton representing the centers of the tracts shared by all participants, and the skeleton was thresholded at FA > 0.20. Each participant’s aligned FA data were projected onto the skeleton, taking on the FA value from the local center of the nearest relevant tract. RD and AD skeletons for each participant were formed in a similar manner by projecting the analogous data onto the mean skeleton. […]

Pipeline specifications

Software tools FSL, BET
Application Magnetic resonance imaging
Organisms Homo sapiens