Computational protocol: Age-Dependent Protein Aggregation Initiates Amyloid-β Aggregation

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Protocol publication

[…] Human homologs of early-aggregating proteins and late-aggregating proteins in C. elegans (as described in the results) were identified using cildb 3.0 and Ensembl genome browser 87. 83 human homologs of early-aggregating proteins and 116 human homologs of late-aggregating proteins including early-aggregating proteins that continued to aggregate strongly at day 10 and day 14 were analyzed together with 161 minor components of AD pathological aggregates previously published (; ; ) using Ingenuity Pathway Analysis (IPA; Winter Release 2016). Fisher’s exact test was used to calculate a p-value reflecting the probability that the association between the set of molecules and a given pathway is due to chance alone. Our threshold of the p-value for association was set to 0.01. […]

Pipeline specifications

Software tools Array Suite, IPA
Databases Cildb
Application Genome data visualization
Organisms Caenorhabditis elegans, Mus musculus
Diseases Alzheimer Disease, Blood Protein Disorders, Neurodegenerative Diseases