Differentiation of acute myeloid leukemia cells

We developed a general approach to small molecule library screening called GE-HTS (Gene Expression-Based High Throughput Screening) in which a gene expression signature is used as a surrogate for cellular states and applied it to the identification of compounds inducing the differentiation of acute myeloid leukemia cells. In screening 1,739 compounds, we identified 8 that reliably induced the differentiation signature, and furthermore yielded functional evidence of bona fide differentiation. This SuperSeries is composed of the SubSeries listed below.

Dataset features

Information

Specifications

Application:	Gene expression microarray analysis
Number of samples:	117
Release date:	Jan 30 2004
Last update date:	Aug 10 2018
Access:	Public
Diseases:	Leukemia, Myeloid, Acute
Dataset link	Differentiation of acute myeloid leukemia cells

Experimental Protocol

Refer to individual Series

Repositories

GEO

GSE995

ArrayExpress

E-GEOD-995

BioProject

PRJNA88047

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Contact

Ken Ross