|Application:||Gene expression microarray analysis, miRNA array analysis|
|Number of samples:||158|
|Release date:||Jan 16 2014|
|Last update date:||May 2 2017|
|Diseases:||Brain Neoplasms, Carcinoma, Colonic Diseases, Colonic Neoplasms, Neoplasms, Rectal Neoplasms, Tumor Lysis Syndrome|
|Dataset link||Impact of miRNAs modulation on regulatory networks and pathways involved in colon cancer and metastasis development|
We determined miRNA expression profile for 78 samples comprising 23 normal adjacent mucosa (N), 31 primitive colorectal cancer (T) and 24 liver metastases (M), obtained from 45 patients who underwent surgery at University of Padova (Surgery Branch, Department of Oncological and Surgical Sciences) between March 1994 and September 2008. This dataset included 24 samples belonging to 8 patients with matched samples (N, T and M) from the same patients. We also examined the expression profiles for 80 samples, comprising 23 N, 30 T, 27 M, and including 27 per-patient matched samples from 9 patients. Considering both miRNAs and genes expression experiments, we obtained a set of 77 samples (23N, 30T, 24M) with matched miRNAs and genes expression data from the same biological sample, to reconstruct post-transcriptional regulatory networks.
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