Dataset features

Specifications


Application: RNA-seq analysis
Number of samples: 50
Release date: Nov 12 2018
Last update date: Nov 29 2018
Access: Public
Diseases: Leukemia
Genes: CHAF1B, CEBPA
Dataset link A CHAF1B-dependent molecular switch in hematopoiesis and leukemia pathogenesis

Experimental Protocol


Examination of the function of CHAF1B in maintaining undifferentiated state of leukemic cells. We used Chaf1b-floxed MLL-AF9 leukemic cell clones which were transduced with CreERT2. Knockout was induced by treatment with B-estradiol, and cells were lysed 48 hours after induction for analysis. Floxed cells expressing CreERT2 treated with EtOH were used as clonal controls.

Repositories


GEO

GSE120063

ENA

SRP161931

BioProject

PRJNA491485

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Contact


Elizabeth Bartom