|Number of samples:||50|
|Release date:||Nov 12 2018|
|Last update date:||Nov 29 2018|
|Dataset link||A CHAF1B-dependent molecular switch in hematopoiesis and leukemia pathogenesis|
Examination of the function of CHAF1B in maintaining undifferentiated state of leukemic cells. We used Chaf1b-floxed MLL-AF9 leukemic cell clones which were transduced with CreERT2. Knockout was induced by treatment with B-estradiol, and cells were lysed 48 hours after induction for analysis. Floxed cells expressing CreERT2 treated with EtOH were used as clonal controls.