|Application:||Gene expression microarray analysis|
|Number of samples:||283|
|Release date:||Dec 7 2016|
|Last update date:||Mar 6 2018|
|Dataset link||Rational selection of syngeneic preclinical tumor models for immunotherapeutic drug discovery [exon array]|
Mouse syngeneic tumour cell lines were grown in vitro n=1 and in vivo n ≈5 subcutaneously on the backs of mice from their parental strain or orthotopically (see sample records for specific details for each mouse model). Mice were sacrificed when tumours reached an average of 200 mm3. In vitro samples underwent aCGH analysis and transcriptomics analysis while in vivo tumor samples along with a draining lymph node and spleen sample were taken from the same mouse and underwent transcriptomics analysis. Whole exome sequencing and immunophenotyping were also performed on these syngeneic models to in all give a multiomic characterisation of these models.