Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 283
Release date: Dec 7 2016
Last update date: Mar 6 2018
Access: Public
Diseases: Neoplasms
Dataset link Rational selection of syngeneic preclinical tumor models for immunotherapeutic drug discovery [exon array]

Experimental Protocol


Mouse syngeneic tumour cell lines were grown in vitro n=1 and in vivo n ≈5 subcutaneously on the backs of mice from their parental strain or orthotopically (see sample records for specific details for each mouse model). Mice were sacrificed when tumours reached an average of 200 mm3. In vitro samples underwent aCGH analysis and transcriptomics analysis while in vivo tumor samples along with a draining lymph node and spleen sample were taken from the same mouse and underwent transcriptomics analysis. Whole exome sequencing and immunophenotyping were also performed on these syngeneic models to in all give a multiomic characterisation of these models.

Repositories


GEO

GSE85507

BioProject

PRJNA338687

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Contact


John Prime