Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 19
Release date: Jun 1 2014
Last update date: Aug 31 2014
Access: Public
Diseases: Amyotrophic Lateral Sclerosis, TDP-43 Proteinopathies
Dataset link Loss of nuclear TDP-43 in ALS causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurons [fibroblasts]

Experimental Protocol


RNA was extracted from fibroblasts grown from neurologically healthy controls (n=6) and 3 groups of patients with ALS: 1) sporadic cases (n=6); 2) cases due to mutations of SOD1 (n=4); 3) cases due to mutations of TARDBP (n=3). The three ALS groups were compared to the controls.

Repositories


GEO

GSE33855

ArrayExpress

E-GEOD-33855

BioProject

PRJNA148163

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Contact


Paul Heath
Paul Roy Heath