|Application:||Gene expression microarray analysis|
|Number of samples:||19|
|Release date:||Jun 1 2014|
|Last update date:||Aug 31 2014|
|Diseases:||Amyotrophic Lateral Sclerosis, TDP-43 Proteinopathies|
|Dataset link||Loss of nuclear TDP-43 in ALS causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurons [fibroblasts]|
RNA was extracted from fibroblasts grown from neurologically healthy controls (n=6) and 3 groups of patients with ALS: 1) sporadic cases (n=6); 2) cases due to mutations of SOD1 (n=4); 3) cases due to mutations of TARDBP (n=3). The three ALS groups were compared to the controls.
Paul Roy Heath