Computational protocol: Transdermal fentanyl as an adjuvant to paravertebral block for pain control after breast cancer surgery: A randomized, double-blind controlled trial

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Protocol publication

[…] The sample size was calculated using the G*Power© software (Institut für Experimentelle Psychologie, Heinrich-Heine-Universität, Düsseldorf, Germany) version 3.1.9.2. In a previous study,[] using TFP reduced morphine consumption during the first 24 postoperative hours to 15.4 ± 12.7 mg compared 33.6 ± 19.1 mg in the placebo-controlled group. Based on the results of this study, a sample of 18 patients in each group is required to elicit the difference at an alpha level of 0.05 and a power of the study of 90%. [...] Statistical analysis of the data was performed using IBM© SPSS© Statistics version 22 (IBM© Corp., Armonk, NY, USA). Numerical variables were presented as a mean and standard deviation or median and range as appropriate. The intergroup differences were compared using the independent samples Student's t-test or Mann–Whitney test for numerical variables. Chi-square test (Fisher's exact test) was used to examine the relation between qualitative variables. Two-way analysis of variance was used to test the interaction between the two groups' effects of hemodynamic variables. All tests were two-sided. A P < 0.05 was considered statistically significant. […]

Pipeline specifications

Software tools G*Power, SPSS
Application Miscellaneous
Organisms Homo sapiens
Chemicals Bupivacaine, Fentanyl, Morphine