Computational protocol: Disease burden for patients with primary immunodeficiency diseases identified at reference hospitals in Guanajuato, Mexico

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Protocol publication

[…] We conducted an observational, longitudinal and comparative study, in five different reference centers or tertiary referral hospitals in the state of Guanajuato, Mexico. Epidemiological and clinical data were obtained by review of clinical files. After this, authors interviewed patients or their relatives, and established a prospective data base using a standard questionnaire to obtain the following variables: family expenses, work/lost school days, mean time at the onset of symptoms, number of visits to emergency room, number of doctors’ visits, insurance coverage, health sector and parental consanguinity; data was obtained using a standard questionnaire. We also collected data regarding cost for day of hospitalization, visit to emergency room (ER), and visits to the physician’s office, directly from the accounting department and financial support of each participant hospital. A total of 44 patients were included and grouped according to the 2015 updated classification of PIDs introduced by the Expert Committee of International Union of Immunological Societies (IUIS) on Primary Immunodeficiency []. Diagnosis was made following the main and current international criteria [][]. The study subjects included in the present survey were patients from the Immunology Department of the different reference centers. The five referral hospitals, at the moment of the study, have a mean of 83,171 active patients; 147.25 hospital beds; 7,113.33 admissions per year; and 7,032.67 outpatients per year. Their influence area comprises the central-bajio region in Mexico, and gives service at least to 6 million people, mainly in the state of Guanajuato.The patients’ parents were considered to be related if parental consanguinity was of the first or second degree. The study was approved by the ethics and research committee of the Hospital Regional de Alta Especialidad del Bajío. Participants included in the study provided their written informed consent. Quantitative variables were described using median with interquartile range (IQR), and mean ± standard deviation (SD). Categorical data were described using absolute and relative frequencies. Regarding to the comparative analysis between patients with IDP before and after treatment with intravenous immunoglobulin (IVIG), data were compared using Wilcoxon signed-rank test. We also compered patient with IDP before and after the treatment with IVIG, with healthy matched controls, using Mann-Whitney U test. The healthy matched controls were siblings or friends of the same gender and similar age, without PID or chronic diseases, except for one who had mild intermittent asthma. Statistical analysis was performed using the Sigmaplot v.12.0 software for Windows and VassarStats. […]

Pipeline specifications

Software tools SigmaPlot, VassarStats
Applications Immune system analysis, Miscellaneous
Organisms Homo sapiens
Diseases Immune System Diseases