Dataset features

Specifications


Application: Gene expression microarray analysis, miRNA array analysis
Number of samples: 57
Release date: Jan 7 2014
Last update date: Jan 7 2014
Access: Public
Diseases: Bone Marrow Diseases
Chemicals: Formaldehyde
Dataset link Formaldehyde-induced changes in microRNA signaling [Agilent]

Experimental Protocol


Male Fischer rats received nose-only inhalation exposures of 2 ppm formaldehyde. Three exposure durations were investigated: (1) 2 ppm formaldehyde exposure, 6 hours/day, for 7 days (7-day group), (2) 2 ppm formaldehyde exposure, 6 hours/day, for 28 days (28-day group), and (3) 2 ppm formaldehyde exposure, 6 hours/day, for 28 days, with a 7 day recovery period following the last exposure (28-day plus recovery group). Control (unexposed) rats were placed in nose-only exposure tubes containing room air for the same duration. After the last exposure period (or the last recovery period for the 28-day plus recovery group), animals were euthanized. RNA were assessed from sampes collected from the nasal epithelium, circulating white blood cells, and bone marrow cells. Genome-wide miRNA expression profiles were evaluated using microarrays.

Repositories


GEO

GSE42393

ArrayExpress

E-GEOD-42393

BioProject

PRJNA181285

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Contact


Rebecca Fry
Rebecca Catherine Fry