|Application:||Gene expression microarray analysis|
|Number of samples:||293|
|Release date:||Feb 14 2012|
|Last update date:||Feb 22 2018|
|Diseases:||Eye Diseases, Macular Degeneration, Geographic Atrophy|
|Dataset link||Systems-level analysis of age-related macular degeneration reveals global and subtype-specific functional pathways|
177 samples from the macular or extramacular region of human donor eye RPE-choroids and 118 samples from the macular or extramacular region of human donor retina with no reported ocular disease, possible preclinical AMD or AMD were analyzed using a two-color universal reference design. The reference RNA was comprised of a 1:1 mixture of pooled RPE-choroid and retina RNA from normal and AMD eyes. Except for two samples, no replicates were performed. The dyes used to label the experimental samples and the reference samples were alternated. The non-Iowa donor eye data was used as a second cohort for verification purposes of global (i.e., non-subtype-specific) expression.
Citations per year