|Application:||Gene expression microarray analysis|
|Number of samples:||16|
|Release date:||Nov 15 2016|
|Last update date:||May 1 2018|
|Diseases:||Neoplasms, Hematologic Neoplasms, Dendritic Cell Sarcoma, Follicular|
|Dataset link||A druggable TCF4- and BRD4-dependent transcriptional network sustains malignancy in blastic plasmacytoid dendritic cell neoplasm|
For shRNA gene expression profiling, Cal-1 and Gen2.2 cells were infected with either Ctrl or TCF4 shRNAs. Following puromycin selection, shRNA expression was induced for 24 hours and 48 hours in Cal-1 cells (n=4), and for 12 hours and 24 hours in Gen2.2 cells (n=4). For JQ1 gene expression profiling, Cal-1 (n=4) and Gen2.2 (n=4) cells were treated with either DMSO or 100 nM JQ1 for 1 hour, 3 hours, 8 hours and 24 hours.