Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 16
Release date: Nov 15 2016
Last update date: May 1 2018
Access: Public
Diseases: Neoplasms, Hematologic Neoplasms, Dendritic Cell Sarcoma, Follicular
Dataset link A druggable TCF4- and BRD4-dependent transcriptional network sustains malignancy in blastic plasmacytoid dendritic cell neoplasm

Experimental Protocol


For shRNA gene expression profiling, Cal-1 and Gen2.2 cells were infected with either Ctrl or TCF4 shRNAs. Following puromycin selection, shRNA expression was induced for 24 hours and 48 hours in Cal-1 cells (n=4), and for 12 hours and 24 hours in Gen2.2 cells (n=4). For JQ1 gene expression profiling, Cal-1 (n=4) and Gen2.2 (n=4) cells were treated with either DMSO or 100 nM JQ1 for 1 hour, 3 hours, 8 hours and 24 hours.

Repositories


GEO

GSE75650

BioProject

PRJNA304975

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Contact


Louis Staudt