|Application:||SNP array data analysis|
|Number of samples:||32|
|Release date:||Feb 14 2018|
|Last update date:||Feb 14 2018|
|Diseases:||Brain Neoplasms, Colorectal Neoplasms, Tumor Lysis Syndrome, Neoplasms, Second Primary|
|Dataset link||Copy Number Profiles of Paired Primary and Metastatic Colorectal Cancer to Investigate Clonal Tumour Changes|
Paired primary CRC and metastatic liver tumour DNA, and normal patient DNA was assayed with the Omni 2.5-8, V1.0 and V1.1 IlluminaBeadChips as per manufacturer’s instructions (Illumina). SNP arrays were scanned on an iScan (Illumina), data was processed using the Genotyping module (v.1.9.4) in GenomeStudio v.2011.1 (Illumina) to calculate B-allele frequencies (BAF) and logR ratios. GAP software was used to segment the SNP array data and determine the level of copy number which was classified into one of 5 categories: homozygous deletion (copy number: 0), loss (copy number:1), copy neutral LOH (copy number:2), gain (copy number: 3-5) and amplification (copy number: 6-8).
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