Dataset features

Specifications


Application: ChIP-seq analysis, RNA-seq analysis
Number of samples: 56
Release date: Jun 1 2016
Last update date: Oct 24 2018
Access: Public
Genes: TCF4, IGH, AICDA, PRDM1, IGK
Dataset link Essential role of the transcription factors E2A and E2-2 in germinal center B cell and plasma cell development

Experimental Protocol


56 samples in total: A) 38 RNA-Seq samples in 5 cell types: Follicular B cells (FO B cell, 2 genotypes, 2 replicates each) Activated B cells (Act B cell, 2 genoytpes, 6 stimulations, 2 replicates each) Pre-Plasmablasts (Pre-PB, 1 genotype, 2 stimulations, 2 replicates each) Plasmablasts (PB, 1 genotype, 2 stimulations, 2 replicates each) Germline Center B cells (GC B cell, 1 genotype, 2 replicates); B) 13 ChIP-Seq samples in 5 cell types: FO B cell (E2A, 2 crosslinking types, 1 replicate each) Act B cell (E2A, 2 crosslinking types, 2 stimulations, 1 replicate each; H3K27ac, 1 crosslinking type, 1 stimulation, 2 genotypes, 1 replicate each) Pre-PB (E2A, 2 crosslinking types, 1 stimulation, 1 replicate each) PB (E2A, 2 crosslinking types, 1 stimulation, 1 replicate each) Mature B cell (input); C) 5 ATAC Seq samples in 2 cell types: Act B cell (2 stimulations, 2 genotypes, 1 replicate each), Pre-PB (1 stimulation, 1 genotype, 1 replicate).

Repositories


GEO

GSE77744

ArrayExpress

E-GEOD-77744

ENA

SRP069831

BioProject

PRJNA311335

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Contact


Markus Jaritz

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