|Application:||Gene expression microarray analysis|
|Number of samples:||24|
|Release date:||Dec 30 2006|
|Last update date:||Jul 1 2016|
|Diseases:||Autoimmune Diseases, Polyneuropathies|
|Dataset link||Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: analysis by mRNA profiling|
Analysis of two thymic populations - early single positive thymocytes (CD4+CD8lowCD69+TCRhi) and early double positive thymocytes (CD4+CD8+CD69-TCRlow). Samples purified from the 3A9 TCR transgenic (TCR) to characterise positive selection and the 3A9 TCR x insHEL double transgenic (Dbl) to characterise negative selection towards an Aire-dependent organ-specific antigen. Both the non autoimmune C57BL10.H2k (B10) and autoimmune Non obese diabetic (NOD) strains were analysed in this method. Three biological replicates were used for each of these eight different groups.
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