Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 230
Release date: Apr 25 2013
Last update date: Dec 3 2015
Access: Public
Diseases: Alzheimer Disease
Dataset link Multi-tissue gene expression profiles of human brain (PFC)

Experimental Protocol


Autopsied tissues from dorsolateral prefrontal cortex (PFC), visual cortex (VC) and cerebellum (CR) in brains of LOAD patients, and non-demented healthy controls, collected through the Harvard Brain Tissue Resource Center (HBTRC), were profiled on a custom-made Agilent 44K array (GPL4372_1). All subjects were diagnosed at intake and each brain underwent extensive LOAD-related pathology examination. Gene expression analyses were adjusted for age and sex, postmortem interval (PMI) in hours, sample pH and RNA integrity number (RIN). In the overall cohort of LOAD and non-demented brains the mean ± SD for sample PMI, pH and RIN were 17.8±8.3, 6.4±0.3 and 6.8±0.8, respectively. 230 samples with all PFC, VC, and CR tissue profiled were included for further multi-tissue analysis.

Repositories


GEO

GSE44770

ArrayExpress

E-GEOD-44770

BioProject

PRJNA191618

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Contact


Jun Zhu