A database and web server of human whole-genome single nucleotide variants and their functional predictions. dbWGFP collects nearly 8.58 billion possible SNVs across the whole human genome, with each SNV described by 48 functional prediction scores and 44 valuable annotations. dbWGFP is a large-scale comprehensive database for functional predictions and annotations of human whole-genome SNVs. This database can not only be helpful in the capture of causative variants from massive candidates derived from whole-genome or exome sequencing data, but also provide a valuable resource in the study of human genetic variants. dbWGFP offers a user-friendly web interface to facilitate the access of the database. The web interface provides two main components: a query service for retrieving functional prediction scores and annotations of SNVs in different data formats and a download service for setting up a local version of this database. In the step-by-step mode of the query service, users can upload a file containing query variants and retrieve results online. In the batch query mode, users can upload a file containing query variants and an email address.