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A database and web server of human whole-genome single nucleotide variants and their functional predictions. dbWGFP collects nearly 8.58 billion possible SNVs across the whole human genome, with each SNV described by 48 functional prediction scores and 44 valuable annotations. dbWGFP is a large-scale comprehensive database for functional predictions and annotations of human whole-genome SNVs. This database can not only be helpful in the capture of causative variants from massive candidates derived from whole-genome or exome sequencing data, but also provide a valuable resource in the study of human genetic variants. dbWGFP offers a user-friendly web interface to facilitate the access of the database. The web interface provides two main components: a query service for retrieving functional prediction scores and annotations of SNVs in different data formats and a download service for setting up a local version of this database. In the step-by-step mode of the query service, users can upload a file containing query variants and retrieve results online. In the batch query mode, users can upload a file containing query variants and an email address.

Restrictions to use:
None
Programming languages:
Java, PHP
Database management system:
MySQL
Community driven:
No
Data access:
File download, Web user interface
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Institution(s)

MOE Key Laboratory of Bioinformatics, Bioinformatics Division and Center for Synthetic & Systems Biology, TNLIST, Department of Automation, Tsinghua University, Beijing, China

Funding source(s)

This research was partially supported by the National Basic Research Program of China (2012CB316504), the National High Technology Research and Development Program of China (2012AA020401), the National Natural Science Foundation of China (61175002, 61573207) and Beijing Collaborative Innovation Center for Cardiovascular Disorders.

  • (Wu et al., 2016) dbWGFP: a database and web server of human whole-genome single nucleotide variants and their functional predictions. Database.
    PMID: 26989155
  • Animals
    • Homo sapiens
  • (Johnston and Biesecker, 2013) Databases of genomic variation and phenotypes: existing resources and future needs. Human molecular genetics.
    PMID: 23962721

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