Computational protocol: Cognitive Function and Brain Atrophy Predict Non-pharmacological Efficacy in Dementia: The Mihama-Kiho Scan Project2

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Protocol publication

[…] MRI data were analyzed using SPM12 (Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom) implemented in MATLAB R2012a (MathWorks, Natick, MA, United States). In the pre-processing phase, images were set to match the anterior to posterior commissure line using an automated MATLAB script. The images were then visually inspected to check for possible scan issues such as field distortion and movement artifacts. Reoriented images were corrected for intensity inhomogeneity and segmented into GM, white matter, cerebrospinal fluid, and other tissues outside the brain using SPM12 tissue probability maps. The images were registered to the East Asian Brains International Consortium for Brain Mapping space template via affine regularization. We created a population-specific template using the SPM12 DARTEL template procedure to directly compare data between the IMP and no-IMP subgroups. We investigated group differences in GM volume, as well as the relationship between neuropsychological assessment results and GM at the whole-brain level. High-dimensional DARTEL was used to create non-linear, modulated-normalized GM and white matter images, which were smoothed using a Gaussian kernel of 8 mm FWHM (full-width at half-maximum). For whole-brain and multiple regression analyses, we assessed the statistical significance at a voxel threshold of p < 0.005 (uncorrected), within contiguous clusters of at least 20 voxels. We obtained both MNI and Talairach coordinates to detect the anatomical regions of the clusters. We used a transform from Matthew Brett to convert MNI coordinates to Talairach coordinates, and Talairach Client 2.4.3 () was used to identify the anatomical regions corresponding to Talairach coordinates. [...] Differences in demographic variables and neuropsychological assessment results between the IMP and no-IMP subgroups were analyzed using independent t-tests for continuous data, chi-square tests for dichotomous data, and Mann–Whitney U tests for non-parametric data. Differences of p < 0.05 were considered statistically significant. Statistical analyses were performed using IBM SPSS Statistics software version 20 (IBM Corp., Armonk, NY, United States). […]

Pipeline specifications

Software tools SPM, SPSS
Applications Miscellaneous, Magnetic resonance imaging
Organisms Homo sapiens
Diseases Dementia