Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 6
Release date: May 14 2013
Last update date: Aug 23 2018
Access: Public
Diseases: Alzheimer Disease, Cardiovascular Diseases, Amyloid Neuropathies
Chemicals: Angiotensins, Captopril
Dataset link Hippocampal gene expression profiling of a model of Alzheimer`s Disease upon treatment with the ACE inhibitor captopril

Experimental Protocol


Microarray gene expression profiling was performed of hippocampi isolated from aged, 18 month-old Tg2576 (APPSwe-transgenic) AD mice with high Abeta plaque load relative to age-matched Tg2576 mice, which were treated for 6 months with the centrally active ACE inhibitor captopril. Another study group consisted of 12 month-old Tg2576 mice with low Abeta plaque load. In total, three study groups were analyzed, i.e. (i) 18 month-old untreated Tg2576 mice with high Abeta plaque load, (ii) age-matched Tg2576 mice treated for 6 months with the brain-penetrating ACE inhibitor captopril (20 mg/kg body weight/day in drinking water), and (iii) untreated 12 month-old Tg2576 mice with low Abeta plaque load reflecting the time point when captopril treatment was initiated. Two biological replicates were made of each group, and total hippocampal RNA of four mice was pooled for one gene chip.

Repositories


GEO

GSE46871

ArrayExpress

E-GEOD-46871

BioProject

PRJNA202897

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Contact


Ursula Quitterer

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