Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 20
Release date: Jun 3 2014
Last update date: Aug 10 2018
Access: Public
Dataset link Transcripts differentially expressed in healthy blood mDCs compared to healthy monocytes

Experimental Protocol


To directly compare the SLE monocyte transcriptional program with that of blood mDC precursors, we purified lineage HLA-DRhighCD11chigh mDCs and CD14+ monocytes from the blood of five healthy donors. Their gene expression profiles were then compared to those of blood SLE monocytes. An unsupervised clustering analysis of transcripts present in >20% of the samples classified healthy monocytes, SLE monocytes and healthy mDCs into three well defined groups. A supervised analysis was then performed to find genes: 1) differentially expressed in healthy mDCs compared to monocytes; 2) shared by healthy blood mDCs and SLE blood monocytes.

Repositories


GEO

GSE46913

ArrayExpress

E-GEOD-46913

BioProject

PRJNA203038

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