|Application:||Gene expression microarray analysis|
|Number of samples:||44|
|Release date:||Jul 1 2007|
|Last update date:||Mar 16 2012|
|Diseases:||Heart Failure, Cardiomyopathies, Myocardial Ischemia, Ventricular Dysfunction, Left, Ventricular Dysfunction|
|Dataset link||Myocardial gene expression of hibernating and control tissue from patients with ischemic left ventricular dysfunction|
Methods: We compared in patients with advanced coronary artery disease and impaired left ventricular function the gene expression profile of myocardial biopsies from hibernating myocardium (n=5), as identified in PET by a mismatch between perfusion and glucose metabolism, with expression profiles of matched biopsies from remote myocardium. Gene-specific PCR of selected genes was used to validate our technical approach. Immunohistochemical staining was performed for one gene of specific interest.