Computational protocol: Predictive role of high sensitivity troponin T within four hours from presentation of acute coronary syndrome in elderly patients

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Protocol publication

[…] Sensitivity, specificity, negative predictive value (NPV) and positive predictive value (PPV) were analysed for HsTnT cut-off values at 3–4 h and for the combination of a cut-off value at presentation and an absolute change from 0 to 3–4 h. The different cut-off values were pre-specified and based on previous studies [, ]. Sensitivity and specificity with 95 % confidence intervals were calculated. A sensitivity of ≥ 98 % was considered as a clinically acceptable rule out level [].Receiver operating characteristic (ROC) curves were created and the areas under the curves (AUROC) compared for absolute and relative HsTnT changes (in percent) from presentation to 3–4 h. IBM SPSS Statistics 18 (New York, USA) was used for statistical analyses, and a p < 0.05 was regarded as statistically significant.For calculations of 95 % confidence intervals (CI) VassarStats clinical calculator (Vassar College, Poughkeepsie, NY: http://faculty.vassar.edu/lowry/clin1.html) was used. […]

Pipeline specifications

Software tools SPSS, VassarStats
Application Miscellaneous
Organisms Homo sapiens, Plum pox virus
Diseases Myocardial Infarction, Acute Coronary Syndrome