Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 33
Release date: Sep 27 2007
Last update date: Dec 6 2012
Access: Public
Diseases: Leukemia, Precursor Cell Lymphoblastic Leukemia-Lymphoma
Mutations: g|SUB|G|4112|A
Dataset link Five distinct biological processes and 14 differentially expressed genes characterize TEL/AML1-positive leukemia

Experimental Protocol


We carried out a prospective multicentric study on childhood B-ALL leukemia to elucidate the molecular processes involved in TEL/AML1-positive leukemia. All the patients included in this study received treatment according to the French FRALLE 2000 trial. We used Agilent whole-genome oligo-chips (44K-G4112A) to compare the gene expression signatures of TEL/AML1-positive patients to those of TEL/AML1-negative patients with no recurrent chimeric products irrespective of their clinical risk category. Previous microarray gene expression studies had revealed the effect of chromosomal alteration on transcription profiles, so we excluded from our cohort those patients with other recurrent chromosomal translocations or fusion transcripts (BCR/ABL, E2A/PBX1, MLL rearrangements). We then searched for the biological pathways associated with genes differentially expressed in TEL/AML1-positive leukemia (ETV6/RUNX1).

Repositories


GEO

GSE9170

ArrayExpress

E-GEOD-9170

BioProject

PRJNA102731

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Contact


virginie gandemer

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