|Application:||Gene expression microarray analysis|
|Number of samples:||11|
|Release date:||Apr 1 2012|
|Last update date:||Jul 26 2018|
|Diseases:||Leukemia, Hairy Cell, Lymphatic Diseases, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma|
|Dataset link||Engraftment of limited numbers of pediatric leukemia into NOD/SCID/IL2Rcg-null mice enables surrogate markers for clinical outcome|
In the present study, we thus engrafted NSG mice with 18 different pediatric B cell precursor ALL, AML and T-ALL samples and could demonstrate that NSG-derived blasts retained their leukemogenic profile with respect to immune-phenotype, chromosomal aberrations, transcriptome, flowcytometric- and PCR-minimal residual disease (MRD) marker expression.