Computational protocol: Childhood Trauma is Associated with Altered Cortical Arousal: Insights from an EEG Study

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Protocol publication

[…] The EEG data were collected with the use of EEG100C amplifier modules that were attached to the MP150 acquisition system (Biopac Systems Inc.). Electrodes of interest included: left frontal (F3), right frontal (F4), left parietal (P3), and right parietal (P4), with linked ears reference. The EEG data were sampled at 500 Hz on-line; band pass filtered using a Hamming window, 0.05–30 Hz off-line. Relative frequency band powers were extracted after the data had been subjected to Fast Fourier transformation. The relative frequency band powers extracted include: theta (θ, 4–7 Hz), alpha (α, 7–14 Hz), and beta (β, 15–30 Hz).The ERPs were extracted from digital inputs (using E-prime software) for each of the GNG conditions. Individual ERPs that were greater than +100 μV or less than -100 μV were rejected. The ERPs were baseline corrected 100 ms prior to stimulus presentation, and visually inspected. The P300 window was set between 250 and 500 ms after stimulus presentation, the amplitude was the point at which the height of the P300 peak was maximal and latency the time taken to achieve maximum amplitude. The P300 amplitudes and latencies were extracted from the parietal electrodes (P3 and P4). [...] Statistica 9 was used for the statistical analyses. Non-parametric statistics were used to analyze all data, since the Shapiro–Wilks W test revealed that the data set was not normally distributed.To determine significant differences between stages (resting eyes open (REO), resting eyes closed (REC), and the GNG task) and conditions of the GNG task (first go condition, first no-go condition, go 3500 condition, second no-go condition, and second go condition) Friedman analyses of variance (ANOVA) were performed. If the ANOVA revealed a significant effect, it was followed by a Wilcoxon matched pairs test. Data are reported as mean ± SEM.To determine significant correlations between the scores on the Childhood Trauma Questionnaire and physiological measurements recorded during the testing stages (resting eyes open, resting eyes closed, and the GNG task) and conditions of the GNG task (first go condition, first no-go condition, go 3500 condition, second no-go condition, and second go condition) Spearman’s rank order correlation analyses were performed. These data are reported as rho coefficients with their p-values. […]

Pipeline specifications

Software tools E-Prime, Statistica
Applications Miscellaneous, Neuropsychology analysis
Diseases Wounds and Injuries, Substance-Related Disorders
Chemicals Hydrocortisone