Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 221
Release date: Jul 18 2017
Last update date: Aug 9 2018
Access: Public
Diseases: Pulmonary Disease, Chronic Obstructive
Dataset link Distal-to-Proximal Re-patterning of Small Airway Epithelium in Smoking-associated Chronic Obstructive Pulmonary Disease

Experimental Protocol


In this study, distal and proximal human airway epithelial transcriptome signatures were identified by genome-wide analysis of the epithelial samples obtained by bronchoscopic brushings from the distal and proximal airways of healthy nonsmokers. Expression of the identified distal and proximal signatures were then analyzed in the small airway epithelium (SAE) of smokers with COPD compared to that of healthy smokers and healthy nonsmokers. A dramatic smoking-dependent suppression of the distal signature expression accompanied by up-regulation of the proximal signature genes was observed in the SAE of COPD smokers, a novel pathologic feature of COPD-associated small airway disordering designated “distal-proximal re-patterning” of the SAE.

Repositories


GEO

GSE64614

BioProject

PRJNA271408

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Contact


Yael Strulovici-Barel