|Application:||Gene expression microarray analysis|
|Number of samples:||221|
|Release date:||Jul 18 2017|
|Last update date:||Aug 9 2018|
|Diseases:||Pulmonary Disease, Chronic Obstructive|
|Dataset link||Distal-to-Proximal Re-patterning of Small Airway Epithelium in Smoking-associated Chronic Obstructive Pulmonary Disease|
In this study, distal and proximal human airway epithelial transcriptome signatures were identified by genome-wide analysis of the epithelial samples obtained by bronchoscopic brushings from the distal and proximal airways of healthy nonsmokers. Expression of the identified distal and proximal signatures were then analyzed in the small airway epithelium (SAE) of smokers with COPD compared to that of healthy smokers and healthy nonsmokers. A dramatic smoking-dependent suppression of the distal signature expression accompanied by up-regulation of the proximal signature genes was observed in the SAE of COPD smokers, a novel pathologic feature of COPD-associated small airway disordering designated “distal-proximal re-patterning” of the SAE.