Dataset features

Specifications


Dataset type: Genome binding/occupancy profiling by high throughput sequencing, Epigenomics
Number of samples: 9
Release date: Dec 23 2017
Last update date: Oct 18 2018
Access: Public
Diseases: Breast Neoplasms
Chemicals: Progestins, Ribose
Genes: PARP1, PARG, NUDT5
Dataset link ADP-ribose derived Nuclear ATP is Required for Chromatin Remodeling and Hormonal Gene Regulation

Experimental Protocol


1) Hormonal gene regulation requires synthesis of PAR and its degradation to ADPribose by PARG. 2) ADP-ribose is converted to ATP in the cell nuclei by hormone-activated NUDIX5/NUDT5. 3) Blocking nuclear ATP formation precludes hormone-induced chromatin remodeling, gene regulation and cell proliferation.

Repositories


GEO

GSE64467

ENA

SRP051504

BioProject

PRJNA271077

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Contact


Miguel Beato