|Dataset type:||Genome binding/occupancy profiling by high throughput sequencing, Epigenomics|
|Number of samples:||9|
|Release date:||Dec 23 2017|
|Last update date:||Oct 18 2018|
|Genes:||PARP1, PARG, NUDT5|
|Dataset link||ADP-ribose derived Nuclear ATP is Required for Chromatin Remodeling and Hormonal Gene Regulation|
1) Hormonal gene regulation requires synthesis of PAR and its degradation to ADPribose by PARG. 2) ADP-ribose is converted to ATP in the cell nuclei by hormone-activated NUDIX5/NUDT5. 3) Blocking nuclear ATP formation precludes hormone-induced chromatin remodeling, gene regulation and cell proliferation.