Dataset features

Specifications


Application: Gene expression microarray analysis, miRNA array analysis
Number of samples: 29
Release date: May 6 2013
Last update date: May 2 2017
Access: Public
Dataset link Successful and failed human liver regeneration are characterized by the coordinated expression of distinct microRNAs

Experimental Protocol


We compared a group of seven patients with successful regeneration (RG) after auxiliary liver transplant (ALT) to four patients who also had ALT but failed to regenerate (NRG). Regeneration was quantified by volume expansion using radiographic imaging; functional recovery was assessed using nuclear isotope scanning and hepatocellular regeneration using histology. Based on histological assessment, three time points were selected for both groups (RG and NRG). Biopsies were taken at the time of transplant and at different intervals post-transplant. Since sample acquisition was driven by clinical necessity, widely discrepant time intervals existed between T=1, T=2 and T=3 for the patients. RNA was extracted from archived histology samples of the RG and NRG, and miRNA expression was analysed using the Affymetrix GeneChip miRNA 1.0 assays. This submission does not include NRG samples taken at time point 3.

Repositories


GEO

GSE36146

ArrayExpress

E-GEOD-36146

BioProject

PRJNA152963

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Contact


siamak salehi