Computational protocol: Donor PPARα Gene Polymorphisms Influence the Susceptibility to Glucose and Lipid Disorders in Liver Transplant Recipients

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Protocol publication

[…] The quantitative variables were expressed as mean ± standard deviation or median and compared by Student t test or Mann–Whitney U test. The categorical variables were presented as values (percentage) and compared by Pearson χ2 test. The risk factors for metabolic disorders were evaluated by logistic regression analysis. The correlation was analyzed using Pearson linear regression. Variables with statistical significance in univariate analysis were transferred to a stepwise forward multivariate regression analysis. Haploview software and SNPStats web tool (http://bioinfo.iconcologia.net/snpstats/start.htm) were used to analyze the Hardy–Weinberg equilibrium and linkage disequilibrium. SPSS version 13.0 (SPSS Inc, Chicago, IL) was used to complete other statistical analysis. A P value of <0.05 was considered to be statistically significant. […]

Pipeline specifications

Software tools Haploview, snpStats
Application GWAS
Organisms Homo sapiens
Diseases Metabolic Diseases, Lipid Metabolism Disorders
Chemicals Glucose, Nucleotides, Tacrolimus