Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 8
Release date: Sep 14 2018
Last update date: Sep 15 2018
Access: Public
Dataset link Modulation of microglia-mediated amyloid-beta clearance with nanoformulated polyphenol through the SIRT1-LDLR pathway

Experimental Protocol


To elucidate the regulatory mechanism of NP(α-M) on LDLR expression, we conducted gene microarray analysis, and interpreted the data via Ingenuity Pathway Analysis, finding that the key genes related to LDLR expression were SIRT1, sterol regulatory element binding protein-2 (SREBP2), cAMP-response element binding protein (CREB) and proprotein convertase subtilisin/kexin type 9 (PCSK9).

Repositories


GEO

GSE119904

BioProject

PRJNA490656

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Contact


Hu Meng