Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 15
Release date: Sep 2 2015
Last update date: Aug 23 2018
Access: Public
Diseases: Breast Neoplasms
Chemicals: Estrogens, Progesterone, Paclitaxel, Taxoids
Dataset link YB-1 affects response to paclitaxel in TNBCs by modulation of EGR1

Experimental Protocol


Given the pleiotropic nature of YB-1, the aim of this study was to understand whether there were mechanisms in addition to those discussed above, by which YB-1 controls response to PTX in TNBCs. We initially followed up two previously studied mechanisms, mediated by ABCB1/MDR1 and DUSP4. We then proceeded to use genomics to identify novel mechanisms by which YB-1 regulates the response of TNBCs to PTX. This analysis identified and experimentally validated EGR1, encoding the early growth response protein 1 (EGR1) as a previously undiscovered mechanism of YB-1-driven PTX resistance.

Repositories


GEO

GSE60964

ArrayExpress

E-GEOD-60964

BioProject

PRJNA260001

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Contact


Daniel Hurley
Daniel Glyn Hurley