|Application:||Gene expression microarray analysis|
|Number of samples:||15|
|Release date:||Sep 2 2015|
|Last update date:||Aug 23 2018|
|Chemicals:||Estrogens, Progesterone, Paclitaxel, Taxoids|
|Dataset link||YB-1 affects response to paclitaxel in TNBCs by modulation of EGR1|
Given the pleiotropic nature of YB-1, the aim of this study was to understand whether there were mechanisms in addition to those discussed above, by which YB-1 controls response to PTX in TNBCs. We initially followed up two previously studied mechanisms, mediated by ABCB1/MDR1 and DUSP4. We then proceeded to use genomics to identify novel mechanisms by which YB-1 regulates the response of TNBCs to PTX. This analysis identified and experimentally validated EGR1, encoding the early growth response protein 1 (EGR1) as a previously undiscovered mechanism of YB-1-driven PTX resistance.
Daniel Glyn Hurley