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Publication for acc-MOTIF
miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR 122 dependence
[…] xed structure (). Although it is tempting to speculate that this more relaxed RNA structure might facilitate miR-122 access to the miRBR region, e.g. by providing access to auxiliary pairing with the ACC motif at nt 87–89, the C83A mutation also facilitated more efficient infection kinetics in the absence of miR-122 (), indicating that mechanisms beyond miR-122 engagement may be at play. HCV, HCVG […]
Helicobacter pylori strains from a Nigerian cohort show divergent antibiotic resistance rates and a uniform pathogenicity profile
[…] A-C motifs correlate with stronger pathology in the patient . Nine of the 14 isolates sequenced here contained an ABC motif arrangement, the other five harbored either an AC motif (three cases), an ACC motif (one case) or an ABCC motif (one case). Conspicuously, a conserved KDKGPE motif was found upstream of the EPIYA-A motif in nine out of 14 sequences, however no correlation with pathology cou […]
DNA Methylation Assessed by SMRT Sequencing Is Linked to Mutations in Neisseria meningitidis Isolates
[…] target motifs, these control sequence motifs displayed no significant deviation, if compared to motif counts at random loci as described above.We have extracted 120 ORFs displaying at least one AC6m ACC motif within the interval from -75bp to their start position, but the current annotations of the large majority of those genes (hypothetical protein, unknown function) did not allow to identify pa […]
Discovery of rare mutations in extensively pooled DNA samples using multiple target enrichment
[…] The DNA sequence context generally has certain influences on sequencing error rates. A few error-prone motifs, such as the GGT/ACC motif, that were identified in this study can be excluded in the analysis when it was predicted or identified. However, it is still hard to deal with a base position where the error rate is close […]
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