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ACC specifications


Unique identifier OMICS_18879
Name ACC
Alternative name Advanced Cell Classifier
Software type Framework/Library
Interface Graphical user interface
Restrictions to use License purchase required
Operating system Unix/Linux, Mac OS, Windows
Programming languages MATLAB
License GNU General Public License version 3.0
Computer skills Medium
Version 2.11
Stability Stable
Source code URL
Maintained Yes




No version available



  • person_outline Peter Horvath

Publications for Advanced Cell Classifier

ACC citations


Development of image analysis software for quantification of viable cells in microchips

PLoS One
PMCID: 5832319
PMID: 29494694
DOI: 10.1371/journal.pone.0193605

[…] ish the conditions, to put the type of treatment (experiment) as PIACG software.In addition, Vaa3D [] is a fast, and versatile 3D/4D/5D Image Visualization and Analysis System for Bioimages. Whereas, Advanced Cell Classifier [] sorts cell phenotypes by immunofluorescence. Indeed, it executes a type of flow cytometry through microscopy and immunofluorescence since it classifies the cells by size vs […]


Intelligent image based in situ single cell isolation

Nat Commun
PMCID: 5768687
PMID: 29335532
DOI: 10.1038/s41467-017-02628-4
call_split See protocol

[…] xtracellular sources. After the segmentation step is complete, 92 single-cell properties describing the intensity, texture, and shape of the nuclei were extracted using CellProfiler and stored in the Advanced Cell Classifier (ACC) format.We used supervised machine-learning algorithms to predict the phenotypic class for every cell in the screens based on the extracted features. Using Advanced Cell […]


A SPOPL/Cullin 3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes

PMCID: 4846373
PMID: 27008177
DOI: 10.7554/eLife.13841.018

[…] r siRNA against the vATPase subunit vATP6V1B2 were used as negative controls. Cytoplasmic dispersion of M1 and other features characteristic for viral uncoating were detected and quantified using the Advanced Cell Classifier program ( import assays were conducted as the uncoating assay with slight modifications. In brief, after virus binding, cells were incubated for […]


Genomics and drug profiling of fatal TCF3 HLF positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options

Nat Genet
PMCID: 4603357
PMID: 26214592
DOI: 10.1038/ng.3362

[…] ell and captured employing the MetaXpress software (Molecular Devices). Images were processed using CellProfiler software (Broad Institute, Cambridge, MA). Cells were classified and counted using the Advanced Cell Classifier software. This software uses random forest classification to assign ALL cells properly. […]


High Content Analysis of Sequential Events during the Early Phase of Influenza A Virus Infection

PLoS One
PMCID: 3709902
PMID: 23874633
DOI: 10.1371/journal.pone.0068450

[…] For the EU, EI, and the NP translation assays, single cell-based (SCB) phenotypic profiling was used based on multi-parametric analysis. For this purpose, we used the Advanced Cell Classifier program (, which allows the user to assign predefined phenotypes to cells. The computer uses this training set to learn a model and to classify unassig […]


1Click1View: Interactive Visualization Methodology for RNAi Cell Based Microscopic Screening

Biomed Res Int
PMCID: 3591157
PMID: 23484084
DOI: 10.1155/2013/156932

[…] nd analysis stages. For illustration, two screens have been taken into visual quality control analysis using Nauru software described in . For each cell of the samples, the image processing software (Advanced Cell Classifier []) quantified the images by calculating more than a hundred parameters, which mainly fall into the following categories:geometric properties such as the area, perimeter, and […]


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ACC institution(s)
Light Microscopy Centre, ETH Zurich, Zurich, Switzerland; Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität, München, Germany; Institute of Biochemistry, ETH Zurich, Zurich, Switzerland

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