ACEt specifications


Unique identifier OMICS_22913
Name ACEt
Software type Package/Module
Interface Command line interface
Restrictions to use None
Input data A matrix format for MZ and DZ twins separately in which each row for a twin pair contains three columns (the first two are phenotypes and the third is age or other moderators of interest).
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
License GNU General Public License version 3.0
Computer skills Advanced
Version 1.8.0
Stability Stable
splines, MASS, Rcpp(≥0.11.1), R(≥3.1.1)
Source code URL
Maintained Yes




No version available



  • person_outline Liang He

Publication for ACEt

ACEt citations


LTD expression is independent of glutamate receptor subtype

PMCID: 4086023
PMID: 25071549
DOI: 10.3389/fnsyn.2014.00015

[…] -5-phosphonopentanoic acid (APV) (Tocris) was included in the experiments in Figure , and 1 μM (S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxy-5-phenylthiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione (ACET) (Tocris) in Figures . Synaptic responses were evoked by stimulating with a 100 μm tungesten bipolar stimulating electrode (FHC, Inc.) in stratum radiatum of CA1. Simultaneous dual whole-cell rec […]


LTP requires a reserve pool of glutamate receptors independent of subunit type

PMCID: 3998843
PMID: 23235828
DOI: 10.1038/nature11775

[…] Neto2 in Gria1-3fl/fl CA1 neurons. In this case, we recorded a population of pure KARs on the surface that desensitize to glutamate even in the presence of cyclothiazide and are completely blocked by ACET, a highly specific GluK1 antagonist (). Furthermore, in this AMPAR-null background, these neurons exhibit EPSCs that are entirely blocked by ACET, while the EPSCs in neighboring controls neurons […]

ACEt institution(s)
Broad Institute of MIT and Harvard, Cambridge, MA, USA; Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA, USA; Department of Public Health, University of Helsinki, Helsinki, Finland; Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland; Population Research Unit, Department of Social Research, University of Helsinki, Helsinki, Finland; Department of Mathematical Sciences, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland
ACEt funding source(s)
Supported, in part, by Academy of Finland (Grant 265240).

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