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As a reversible post-translational modification (PTM) discovered decades ago, protein lysine acetylation was known for its regulation of transcription through the modification of histones. Recent studies discovered that lysine acetylation targets broad substrates and especially plays an essential role in cellular metabolic regulation.
(Liu et al., 2011) CPLA 1.0: an integrated database of protein lysine acetylation. Nucleic Acids Res.