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acslXtreme specifications


Unique identifier OMICS_21538
Name acslXtreme
Software type Application/Script
Interface Graphical user interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Computer skills Medium
Stability No
Maintained No


No version available

acslXtreme citations


Physiologically based pharmacokinetic modeling of tea catechin mixture in rats and humans

PMCID: 5464336
PMID: 28603626
DOI: 10.1002/prp2.305

[…] or humans were formulated as a computer program (see ). After incorporating the different parameter values (Tables , , , , ) into the PBPK model, the equations were solved numerically with the aid of AcslXtreme (AEgis Technologies Group, Inc., Orlando, FL). […]


Physiologically based pharmacokinetic model for ethyl tertiary‐butyl ether and tertiary‐butyl alcohol in rats: Contribution of binding to α2u–globulin in male rats and high‐exposure nonlinear kinetics to toxicity and cancer outcomes

J Appl Toxicol
PMCID: 5434881
PMID: 27885692
DOI: 10.1002/jat.3412

[…] The model was coded in acslXtreme® software (currently not commercially available; originally from AEgis Technologies Group, Huntsville, AL, USA). As described in “PBPK model for ETBE‐TBA,” the structure of the model (Fig.  […]


Risks associated with melamine and related triazine contamination of food

PMCID: 3167660
PMID: 22460395
DOI: 10.3134/ehtj.10.005

[…] flow and tissue volumes), physiochemical (for example, tissue:blood partition coefficients), and biochemical (protein binding, metabolism) in nature. The mathematical modeling and simulation software AcslXtreme (Aegis Technologies Group Inc., Huntsville, AL, USA) can be used for model simulations, parameter estimation, sensitivity analysis, and Monte Carlo analysis. These PBPK models can be easily […]


Bayesian Algorithm Implementation in a Real Time Exposure Assessment Model on Benzene with Calculation of Associated Cancer Risks

PMCID: 3280828
PMID: 22399936
DOI: 10.3390/s90200731

[…] chronic toxicity as well, especially when personal exposure is characterized by short-term but repetitive high values of benzene. The whole PBPK/PD and pathology (cancer risk) model was developed on acslXtreme simulation software by Aegis Technologies. […]


Competitive Inhibition of Thyroidal Uptake of Dietary Iodide by Perchlorate Does Not Describe Perturbations in Rat Serum Total T4 and TSH

Environ Health Perspect
PMCID: 2685834
PMID: 19479014
DOI: 10.1289/ehp.0800111

[…] We constructed the BBDR-HPT axis model in acslXtreme, version 2.4 (AEgis Technologies, Huntsville, AL) and solved it using the Gear algorithm for stiff systems. The model for dietary iodide and the thyroid axis was used as previously describe […]


A Physiologically Based Pharmacokinetic Model for the Assessment of Infant Exposure to Persistent Organic Pollutants in Epidemiologic Studies

Environ Health Perspect
PMCID: 2661921
PMID: 19337526
DOI: 10.1289/ehp.0800047

[…] We performed PBPK modeling and simulations using ACSLXtreme software (Aegis Technologies Group, Inc., Huntsville, AL, USA). We carried out nonparametric correlation analyses (Spearman coefficients) using SPSS for Windows statistical package (SPSS In […]


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