ActionPotential statistics

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Citations per year

Number of citations per year for the bioinformatics software tool ActionPotential
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Tool usage distribution map

This map represents all the scientific publications referring to ActionPotential per scientific context
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ActionPotential specifications

Information


Unique identifier OMICS_22874
Name ActionPotential
Alternative names ApPredict, Action Potential prediction on line, AP-portal, ActionPotential-Portal
Interface Web user interface
Restrictions to use None
Input data A simple concentration-response curve.
Output data A summary graph.
Programming languages C++
License BSD 3-clause “New” or “Revised” License
Computer skills Basic
Stability Stable
Registration required Yes
Maintained Yes

Download


bitbucket.png

Documentation


Maintainers


  • person_outline Gary Mirams
  • person_outline Geoff Williams

Additional information


https://figshare.com/articles/Action_Potential_Prediction_Web_Portal_Documentation/1039436 https://bitbucket.org/gef_work/ap_predict_online http://apportal.readthedocs.io/en/latest/

Information


Unique identifier OMICS_22874
Name ActionPotential
Alternative names ApPredict, Action Potential prediction on line, AP-portal, ActionPotential-Portal
Software type Application/Script
Interface Graphical user interface
Restrictions to use None
Input data A simple concentration-response curve.
Output data A summary graph.
Operating system Unix/Linux
Programming languages C++
License BSD 3-clause “New” or “Revised” License
Computer skills Medium
Version 3.4
Stability Stable
Requirements
Chaste
Maintained Yes

Download


download.png

Versioning


No version available

Documentation


Maintainers


  • person_outline Gary Mirams
  • person_outline Geoff Williams

Additional information


https://figshare.com/articles/Action_Potential_Prediction_Web_Portal_Documentation/1039436 https://bitbucket.org/gef_work/ap_predict_online http://apportal.readthedocs.io/en/latest/

Publication for ActionPotential

ActionPotential citations

 (8)
library_books

Complex versus simple models: ion channel cardiac toxicity prediction

2018
PeerJ
PMCID: 5804316
PMID: 29423349
DOI: 10.7717/peerj.4352

[…] The AP predict platform () which is a web-based cardiac modelling simulation platform (https://appredict.cs.ox.ac.uk) was used to simulate the ORD and TT models in all cases except for one simulation study. A MATLAB version of the ORD model available on the Rudylab website (http://rudylab.wustl […]

library_books

Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro‐arrhythmia Assay initiative studies

2017
Br J Pharmacol
PMCID: 5715595
PMID: 28941245
DOI: 10.1111/bph.14047

[…] ion channel data and summarized in Table , formed the input into our models for simulating action potentials in cardiomyocytes. We ran simulations of ion channel block caused by pitolisant using the ‘ApPredict’ Web Portal (Williams and Mirams, ), with predictions of torsadogenic risk using the model proposed by Grandi et al. () and a method proposed earlier (Mirams et al., ) to predict torsadogeni […]

library_books

Early afterdepolarisation tendency as a simulated pro arrhythmic risk indicator† †Electronic supplementary information (ESI) available. See DOI: 10.1039/C7TX00141J

2017
PMCID: 5779076
PMID: 29456831
DOI: 10.1039/c7tx00141j

[…] Simulations were run using the Chaste C++ framework, with the ApPredict bolt-on project and custom written code. Cell models and initial conditions were imported from CellML files using PyCML.The adaptive timestep solver CVODE was used to solve the model's diffe […]

library_books

Variations in CT determination of target volume with active breath co ordinate in radiotherapy for post operative gastric cancer

2016
PMCID: 4985190
PMID: 26654032
DOI: 10.1259/bjr.20150332

[…] The maximum dimensions from different observers and different CT scans were obtained. X and Y indicated the field width and length of the AP portal and Z indicated the anterior–posterior field extent of the left lateral portal. The average variations of the maximum dimension were 32.5, 22 and 16.24 mm, respectively. ANOVA showed no sign […]

library_books

Assessment of Lipiodol Deposition and Residual Cancer for Hepatocellular Carcinoma After Transcatheter Arterial Chemoembolization via Iodine Based Material Decomposition Images with Spectral Computed Tomography Imaging: A Preliminary Study

2015
PMCID: 4691528
PMID: 26715981
DOI: 10.5812/iranjradiol.26009

[…] 0 mL saline flush by a power injector (Spectris; Medrad, Pittsburgh, PA, USA). The acquisitions were performed at 30 s, 60 s and 180 s after contrast administration during the hepatic arterial phase (AP), portal venous phase (PP) and delayed phase, respectively. […]

library_books

Prediction of Thorough QT study results using action potential simulations based on ion channel screens

2014
J Pharmacol Toxicol Methods
PMCID: 4266452
PMID: 25087753
DOI: 10.1016/j.vascn.2014.07.002

[…] r ‘traditional’ fixed time step solvers for numerically stiff systems such as cardiac action potential models. The software is a custom-made program based on the open-source Chaste library () and its ApPredict (action potential prediction) module.For the interested reader we have made the following resources available: the IC50 datasets, the action potential simulation software; and the scripts fo […]


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ActionPotential institution(s)
Computational Biology, Dept. of Computer Science, University of Oxford, Oxford, UK
ActionPotential funding source(s)
Supported by an EPSRC and NC3Rs Mathematics in Toxicology Strategic Award (NC/K001337/1), an EPSRC Impact Acceleration Account Award (EP/K503769/1) and by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 101222/Z/13/Z).

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