ActiveDriver statistics

Tool stats & trends

Looking to identify usage trends or leading experts?

ActiveDriver specifications

Information


Unique identifier OMICS_00140
Name ActiveDriver
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
License GNU General Public License version 2.0
Computer skills Advanced
Stability Stable
Maintained Yes

Versioning


No version available

Maintainer


  • person_outline Jüri Reimand

Publications for ActiveDriver

ActiveDriver citations

 (3)
library_books

iCAGES: integrated CAncer GEnome Score for comprehensively prioritizing driver genes in personal cancer genomes

2016
Genome Med
PMCID: 5180414
PMID: 28007024
DOI: 10.1186/s13073-016-0390-0

[…] putational tools that use genomic mutations as input, other tools use transcriptomic or post-transcriptomic information as input. Some tools, such as PARADIGM-SHIFT [], DawnRank [], OncoIMPACT[], and ActiveDriver [], provide personal cancer driver gene prediction. However, they require gene expression, phosphorylation, or copy number variation data from patients, all of which are not often feasibl […]

library_books

Frequent mutations in acetylation and ubiquitination sites suggest novel driver mechanisms of cancer

2016
Genome Med
PMCID: 4864925
PMID: 27175787
DOI: 10.1186/s13073-016-0311-2

[…] ent mutations in the pan-cancer dataset. We retrieved continuous PTM-related sequence regions and annotated these to cancer types, PTM classes, and upstream enzymes. This approach is complementary to ActiveDriver as it also highlights proteins that are likely not found by ActiveDriver due to lack of PTM-specific mutational enrichment. These may include short proteins with relatively large PTM regi […]

library_books

Evolutionary Constraint and Disease Associations of Post Translational Modification Sites in Human Genomes

2015
PLoS Genet
PMCID: 4303425
PMID: 25611800
DOI: 10.1371/journal.pgen.1004919

[…] y retaining only the longest isoform of each protein. We compared our annotations of protein substitutions with publicly available annotations of the ESP6500 dataset and found and agreement of 97.7%. ActiveDriver software [] was used to analyze PTM-related substitutions.Functional impact predictions of substitutions of the ESP6500 dataset and the HGMD database were retrieved from five tools (Phylo […]

Citations

Looking to check out a full list of citations?

ActiveDriver institution(s)
The Donnelly Centre, University of Toronto, Toronto, Canada

ActiveDriver reviews

star_border star_border star_border star_border star_border
star star star star star

Be the first to review ActiveDriver