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ActiveDriver specifications


Unique identifier OMICS_00140
Name ActiveDriver
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
License GNU General Public License version 2.0
Computer skills Advanced
Stability Stable
Maintained Yes


No version available


  • person_outline Jüri Reimand

Publications for ActiveDriver

ActiveDriver citations


iCAGES: integrated CAncer GEnome Score for comprehensively prioritizing driver genes in personal cancer genomes

Genome Med
PMCID: 5180414
PMID: 28007024
DOI: 10.1186/s13073-016-0390-0

[…] putational tools that use genomic mutations as input, other tools use transcriptomic or post-transcriptomic information as input. Some tools, such as PARADIGM-SHIFT [], DawnRank [], OncoIMPACT[], and ActiveDriver [], provide personal cancer driver gene prediction. However, they require gene expression, phosphorylation, or copy number variation data from patients, all of which are not often feasibl […]


Frequent mutations in acetylation and ubiquitination sites suggest novel driver mechanisms of cancer

Genome Med
PMCID: 4864925
PMID: 27175787
DOI: 10.1186/s13073-016-0311-2

[…] ent mutations in the pan-cancer dataset. We retrieved continuous PTM-related sequence regions and annotated these to cancer types, PTM classes, and upstream enzymes. This approach is complementary to ActiveDriver as it also highlights proteins that are likely not found by ActiveDriver due to lack of PTM-specific mutational enrichment. These may include short proteins with relatively large PTM regi […]


Evolutionary Constraint and Disease Associations of Post Translational Modification Sites in Human Genomes

PLoS Genet
PMCID: 4303425
PMID: 25611800
DOI: 10.1371/journal.pgen.1004919

[…] y retaining only the longest isoform of each protein. We compared our annotations of protein substitutions with publicly available annotations of the ESP6500 dataset and found and agreement of 97.7%. ActiveDriver software [] was used to analyze PTM-related substitutions.Functional impact predictions of substitutions of the ESP6500 dataset and the HGMD database were retrieved from five tools (Phylo […]


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ActiveDriver institution(s)
The Donnelly Centre, University of Toronto, Toronto, Canada

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