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ADE4 specifications


Unique identifier OMICS_30564
Name ADE4
Alternative name ADE-4
Software type Package/Module
Interface Command line interface, Graphical user interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
Computer skills Advanced
Stability Stable
Maintained Yes




No version available


Additional information

ADE4 citations


Evaluation of the implementation of a clinical pharmacy service on an acute internal medicine ward in Italy

PMCID: 5891983
PMID: 29631587
DOI: 10.1186/s12913-018-2988-y

[…] of practice or that might prevent an adverse drug event (ADE) of moderate importance; 3) major: intervention might prevent serious morbidity, including readmission, serious organ dysfunction, serious ADE; 4) extreme: lifesaving; and 5) deleterious: might lead to adverse outcome []. Clinical significance of interventions was assessed by an independent panel consisting of one clinical pharmacist and […]


Comparative Microbiome Analysis of a Fusarium Wilt Suppressive Soil and a Fusarium Wilt Conducive Soil From the Châteaurenard Region

Front Microbiol
PMCID: 5893819
PMID: 29670584
DOI: 10.3389/fmicb.2018.00568

[…] l–Wallis tests under XLSTAT software (Addinsoft®). The OTU tables obtained from ITS1 and 16S datasets were used to perform an ordination analysis by means of Principal Component Analysis (PCA), using ADE-4 version 2001 (Biometry and Evolutionary Biology Laboratory, University Claude Bernard Lyon 1). For each microbial community, the numbers of unique OTUs and shared OTUs among the different soils […]


Environmental determinism, and not interspecific competition, drives morphological variability in Australasian warblers (Acanthizidae)

Ecol Evol
PMCID: 5916309
PMID: 29721264
DOI: 10.1002/ece3.3925
call_split See protocol

[…] iotic variables: mean annual temperature and annual precipitation. The level of correlation between matrices was assessed by means of Mantel tests with 9,999 random permutations as implemented in the ade4 library (Dray & Dufour, ). […]


Epigenetic Variance, Performing Cooperative Structure with Genetics, Is Associated with Leaf Shape Traits in Widely Distributed Populations of Ornamental Tree Prunus mume

Front Plant Sci
PMCID: 5797549
PMID: 29441078
DOI: 10.3389/fpls.2018.00041

[…] 1 August 2013) values of which were estimated using the daily data downloaded from the database of a Chinese meteorological data sharing service (Supplementary Table ). These data were transformed in ADE-4 software as:where xij represents the value of the ith and jth columns and pi represents the ith row weight ().The AFLP markers were used to investigate genetic diversity and structure. These gen […]


An integrative framework to reevaluate the Neotropical catfish genus Guyanancistrus (Siluriformes: Loricariidae) with particular emphasis on the Guyanancistrus brevispinis complex

PLoS One
PMCID: 5752014
PMID: 29298344
DOI: 10.1371/journal.pone.0189789
call_split See protocol

[…] irwise Monte-Carlo permutation tests on the value of the RV coefficient [] using 9,999 random permutations. Preliminary analyses, permutation tests, and multi-tables analyses were performed using the ade4 package in R. […]


Vasorelaxant effects of Angelica decursiva root on isolated rat aortic rings

BMC Complement Altern Med
PMCID: 5625843
PMID: 28969672
DOI: 10.1186/s12906-017-1965-z

[…] nuded aortic rings by PE (1 μM) or KCl (60 mM) treatment. Preincubation with ADE (100–400 μg/ml) significantly inhibited the contractions induced by extracellular CaCl2 (10 mM) and the contraction at ADE (400 μg/ml) was decreased to 0.29 ± 0.07 g and 0.09 ± 0.05 g compare to the not pre-treated control group 1.53 ± 0.12 g and 1.23 ± 0.09 g, in cells pre-contracted by PE and KCl, respectively (Fig. […]


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